A half century ago electronic fetal monitoring was rushed into clinical use with the promise that the secrets of fetal heart rate decelerations had been discovered and that the newly discovered knowledge would prevent cerebral palsy with just in time cesarean sections preventing babies from experiencing asphyxia, which was thought to be the primary cause of cerebral palsy. In the years since electronic fetal monitoring’s debut, it has been discovered that asphyxia is a rare cause of cerebral palsy. At the (...) same time electronic fetal monitoring use increased to 85% of all labors, the C-section rate increased to 33% without an attributable decrease in the rate of cerebral palsy. What went wrong with electronic fetal monitoring? The answer lies in a new analysis of the physiologic theories concerning fetal heart rate decelerations, demonstrating that the earlier electronic fetal monitoring theories were wrong. This revelation is only the latest evidence that electronic fetal monitoring use today... (shrink)

Op Art contains nine chapters of commentary and of philosophical reflections on Op works. In addition it includes an adequate selection of reproductions, diagrams and illustrations. It is admirably produced and contains a short bibliography and a useful index.

Background: Medical tourism involves patients travelling internationally to receive medical services. This practice raises a range of ethical issues, including potential harms to the patient's home and destination country and risks to the patient's own health. Medical tourists often engage the services of a facilitator who may book travel and accommodation and link the patient with a hospital abroad. Facilitators have the potential to exacerbate or mitigate the ethical concerns associated with medical tourism, but their roles are poorly understood. -/- (...) Methods: 12 facilitators were interviewed from 10 Canadian medical tourism companies. -/- Results: Three themes were identified: facilitators' roles towards the patient, health system and medical tourism industry. Facilitators' roles towards the patient were typically described in terms of advocacy and the provision of information, but limited by facilitators' legal liability. Facilitators felt they played a positive role in the lives of their patients and the Canadian health system and served as catalysts for reform, although they noted an adversarial relationship with some Canadian physicians. Many facilitators described personally visiting medical tourism sites and forming personal relationships with surgeons abroad, but noted the need for greater regulation of their industry. -/- Conclusion: Facilitators play a substantial and evolving role in the practice of medical tourism and may be entering a period of professionalisation. Because of the key role of facilitators in determining the effects of medical tourism on patients and public health, this paper recommends a planned conversation between medical tourism stakeholders to define and shape facilitators' roles. (shrink)

The Alice Books, full of illogical thoughts, words, and contradictions, were unrivaled entertainment until the publication of the medical literature promoting electronic fetal monitoring for every pregnancy. The modern-day EFM advocates acknowledge EFM’s decades long failure but simultaneously recommend EFM use for lawsuit protection and because the profession has used EFM for every pregnancy for fifty years, therefore, it must be efficacious. These self-indulgent, illogical rationalizations ignore the half century of evidence-based scientific research proving that EFM is a complete failure (...) as well as ignoring the fact that continued EFM use violates the fundamental principles of modern bioethics. This blind advocacy perpetuates four pernicious EFM harms occurring to mothers, babies, and the medical profession itself. This article sets out these four EFM harms with the goal of abolishing the misguided, illogical, contradictory, arguments used by the twenty-first century EFM Lewis Carroll mimics. (shrink)

The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

Heterogeneity in mitochondrial content has been previously suggested as a major contributor to cellular noise, with multiple studies indicating its direct involvement in biomedically important cellular phenomena. A recently published dataset explored the connection between mitochondrial functionality and cell physiology, where a non‐linearity between mitochondrial functionality and cell size was found. Using mathematical models, we suggest that a combination of metabolic scaling and a simple model of cell death may account for these observations. However, our findings also suggest the existence (...) of alternative competing hypotheses, such as a non‐linearity between cell death and cell size. While we find that the proposed non‐linear coupling between mitochondrial functionality and cell size provides a compelling alternative to previous attempts to link mitochondrial heterogeneity and cell physiology, we emphasise the need to account for alternative causal variables, including cell cycle, size, mitochondrial density and death, in future studies of mitochondrial physiology. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

Finitary sketches, i.e., sketches with finite-limit and finite-colimit specifications, are proved to be as strong as geometric sketches, i.e., sketches with finite-limit and arbitrary colimit specifications. Categories sketchable by such sketches are fully characterized in the infinitary first-order logic: they are axiomatizable by σ-coherent theories, i.e., basic theories using finite conjunctions, countable disjunctions, and finite quantifications. The latter result is absolute; the equivalence of geometric and finitary sketches requires (in fact, is equivalent to) the non-existence of measurable cardinals.

The teaching of ethics in UK medical schools has recently been reviewed, from the perspective of the teachers themselves. A questionnaire survey of medical undergraduates at King’s College London School of Medicine provides useful insight into the students’ perception of ethics education, what they consider to be the value of learning ethics and law, and how engaged they feel with the subject.

When people engage in conversation, they tailor their utterances to their conversational partners, whether these partners are other humans or computational systems. This tailoring, or adaptation to the partner takes place in all facets of human language use, and is based on a mental model or a user model of the conversational partner. Such adaptation has been shown to improve listeners' comprehension, their satisfaction with an interactive system, the efficiency with which they execute conversational tasks, and the likelihood of achieving (...) higher level goals such as changing the listener's beliefs and attitudes. We focus on one aspect of adaptation, namely the tailoring of the content of dialogue system utterances for the higher level processes of persuasion, argumentation and advice-giving. Our hypothesis is that algorithms that adapt content for these processes, according to a user model, will improve the usability, efficiency, and effectiveness of dialogue systems. We describe a multimodal dialogue system and algorithms for adaptive content selection based on multi-attribute decision theory. We demonstrate experimentally the improved efficacy of system responses through the use of user models to both tailor the content of system utterances and to manipulate their conciseness. (shrink)

The centerpiece of the Analyses is a translation from the German of notes for a series of lectures given by phenomenologist Edmund Husserl in the early twenties, which is to say some eighty years ago. Husserl designated the topic of the lectures 'transcendental logic'. In this context, the term, 'transcendental', is not to be understood in some mystical sense, but rather in a Kantian sense: pertaining to the conditions of possibility of experience. Likewise, the term, 'logic', is not to be (...) taken in the narrow sense of formal logic, but rather in the very general sense it had for Platonic dialectic: a concern with normative guidelines and critical assessment of the possibility of truth. The topic of the lectures is succinctly characterized by Husserl as 'a universal theory of science, and at the same time, a theory of science in principle,' where the latter means 'the science of the a priori of all sciences as such' (p. 1). (shrink)

Since Tversky argued that similarity judgments violate the three metric axioms, asymmetrical similarity judgments have been particularly challenging for standard, geometric models of similarity, such as multidimensional scaling. According to Tversky, asymmetrical similarity judgments are driven by differences in salience or extent of knowledge. However, the notion of salience has been difficult to operationalize, especially for perceptual stimuli for which there are no apparent differences in extent of knowledge. To investigate similarity judgments between perceptual stimuli, across three experiments, we collected (...) data where individuals would rate the similarity of a pair of temporally separated color patches. We identified several violations of symmetry in the empirical results, which the conventional multidimensional scaling model cannot readily capture. Pothos et al. proposed a quantum geometric model of similarity to account for Tversky's findings. In the present work, we extended this model to a more general framework that can be fit to similarity judgments. We fitted several variants of quantum and multidimensional scaling models to the behavioral data and concluded in favor of the quantum approach. Without further modifications of the model, the best-fit quantum model additionally predicted violations of the triangle inequality that we observed in the same data. Overall, by offering a different form of geometric representation, the quantum geometric framework of similarity provides a viable alternative to multidimensional scaling for modeling similarity judgments, while still allowing a convenient, spatial illustration of similarity. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

Respect for autonomy is a central value in reproductive ethics, but it can be a challenge to fulfill and is sometimes an outright puzzle to understand. If a woman requests the transfer of two, three, or four embryos during fertility treatment, is that request truly autonomous, and do clinicians disrespect her if they question that decision or refuse to carry it out? Add a commitment to justice to the mix, and the challenge can become more complex still. Is it unfair (...) for insurance policies to exclude from coverage the costs of giving fertility to those who lack it or restoring fertility in those who have lost it? What does “just reproduction” look like in the face of multifarious understandings of both justice and autonomy and in light of increasingly complex and costly reproductive technologies? In today's dialogue about reproduction, medicine, and ethics in the United States, old ethical issues—such as whether women ought to be allowed to access pregnancy termination—are more contested than they have been in decades, while new technologies—like those used to edit the genes of human embryos—suggest that our species could face unprecedented questions about who should exist. As we considered the discussions accompanying these issues and contemplated a special report responding to them, we found ourselves consistently circling back to two ethical commitments: respect for autonomy and the pursuit of justice. As one of the nine essays in this collection asks, why should certain women receive help to establish a pregnancy while others are thrown in jail when they miscarry or their child is stillborn? Respect for autonomy is required where individuals have the ability to make fully informed and voluntary choices. Yet does respecting autonomy require acceding to all the choices of patients or consumers of medical care? We consider these and related questions in this special report from the Hastings Center Report. (shrink)

When people engage in conversation, they tailor their utterances to their conversational partners, whether these partners are other humans or computational systems. This tailoring, or adaptation to the partner takes place in all facets of human language use, and is based on a mental model or a user model of the conversational partner. Such adaptation has been shown to improve listeners' comprehension, their satisfaction with an interactive system, the efficiency with which they execute conversational tasks, and the likelihood of achieving (...) higher level goals such as changing the listener's beliefs and attitudes. We focus on one aspect of adaptation, namely the tailoring of the content of dialogue system utterances for the higher level processes of persuasion, argumentation and advice‐giving. Our hypothesis is that algorithms that adapt content for these processes, according to a user model, will improve the usability, efficiency, and effectiveness of dialogue systems. We describe a multimodal dialogue system and algorithms for adaptive content selection based on multi‐attribute decision theory. We demonstrate experimentally the improved efficacy of system responses through the use of user models to both tailor the content of system utterances and to manipulate their conciseness. (shrink)

A succinct introduction to mathematical logic and set theory, which together form the foundations for the rigorous development of mathematics. Suitable for all introductory mathematics undergraduates, Notes on Logic and Set Theory covers the basic concepts of logic: first-order logic, consistency, and the completeness theorem, before introducing the reader to the fundamentals of axiomatic set theory. Successive chapters examine the recursive functions, the axiom of choice, ordinal and cardinal arithmetic, and the incompleteness theorems. Dr. Johnstone has included numerous exercises designed (...) to illustrate the key elements of the theory and to provide applications of basic logical concepts to other areas of mathematics. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The power of the application of bioinformatics across multiple publicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme‐responsive nuclear receptors are the most rhythmic transcripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is (...) rhythmically expressed independently of the sleep‐wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied to existing and future data sets will be a powerful tool for the identification of core circadian‐ and sleep‐dependent molecules. (shrink)

Many avenues lead to human consciousness: introspection, phenomenology, cognitive science, philosophy, neurobiology. To these can be added aesthetics; both the production of artful objects and the appreciation of artful objects are characteristic of human minds. By looking at artful objects we can hypothesize why the human mind both produces them and responds to them, and derive from such hypotheses ideas about the nature of human consciousness, including its power to make present in the mind that which is absent from view. (...) In particular, the art of Shakespeare, being both verbal and formal, both articulates the peculiar burdens of human consciousness and demonstrates art's response to these burdens. His play Troilus and Cressida serves as an example, exhibiting and exploring the discordancies human consciousness is liable to, and at the same time incorporating those discordancies into a greater harmony through the formal structures of art. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dharma Bums: The Beat Generation and the Making of Countercultural PilgrimageP. J. JohnstonI believe in the sweetness of Jesus And Buddha— I believe, In St. Francis, Avaloki Tesvara, the Saints Of First Century India A D And Scholars Santidevan And Otherwise Santayanan Everywhere.(Kerouac 1959: 15)Preliminary Polemics“PILGRIM, n. A traveler that is taken seriously.”—Ambrose Bierce, The Devil’s Dictionary 2007: 133As Beat commentator Stephen Prothero describes in his article “On the (...) Holy Road: The Beat Movement as Spiritual Protest” (1991), the Beats and their pilgrimages have most emphatically not been taken seriously. Both critics and scholars have been unkind to members of the Beat generation, and this unkindness has manifested itself in relative neglect of the Beats in all possible aspects of scholarly investigation. But nowhere does this appear more pronounced than in the area of Beat religion. Though some recent scholarship has been picking up from this earlier neglect and it is now [End Page 165] possible to find serious biographies of most of the major Beat writers and some belated attention to the movement as a literary phenomenon, the only book-length treatment of Beat Buddhism I was able to locate (Tonkinson 1995) hardly qualifies as a scholarly work and was published not by an academic press but as a special feature of the Buddhist magazine Tricycle. Prothero hypothesizes that this is because of the movement’s reputation as rebellious and antinomian—in its heyday the movement was characterized in identical unsavory terms by publications representing interests as diverse as Life and Playboy, with the latter describing the Beats as “nihilists” and the former claiming that the Beats were at war with “Mom, Dad, Politics, Marriage, the Savings Bank, Organized Religion, Literary Elegance, Law, the Ivy League Suit and Higher Education, to say nothing of the Automatic Dishwasher, the Cellophane-wrapped Soda Cracker, the Split-Level House and the clean, or peace-provoking H-bomb” (Prothero 1991: 206). Norman Podhoretz of Partisan Review went further still, claiming that the Beats were “hostile to civilization” and that the movement as a whole amounted to “a revolt of the spiritually underprivileged and crippled of soul” and “an affirmation of death” (ibid., 206). One couldn’t ask for a more passionate disavowal of the Beats or a more thorough polemic that the movement was profoundly antireligious.This could not contrast more with the Beats’ representation of their movement and its aims, with Jack Kerouac going so far as to reinterpret the crucial term “Beat” (a term for someone down and out originally borrowed from criminal street jive) as a noun derived from the adjective “beatific,” a specifically religious term familiar from such phrases as “the beatific vision” (ibid., 206–207). Several of the representative Beat writers were practicing Buddhists, influencing the entire movement to such an extent that Buddhist ideas and imagery suffused Beat literature as a whole. Ginsberg and Kerouac especially emphasized the positive and constructive elements of their spiritual vision, arguing that literature such as On the Road and Howl should be understood as religious affirmations of what is good and holy rather than as purely critical undertakings: “For the crucifix I speak out, for the Star of Israel I speak out, for the divinest man who ever lived who was German (Bach) I speak out, for sweet Mohammed I speak out, for Buddha I speak out, for Lao-tse and Chuang-tse I speak out” (ibid., 206–207). Or, as Allen Ginsberg put it less lyrically (and rather more bluntly): “Howl is an ‘Affirmation’ by individual experience of God, sex, drugs, and absurdity... the poems are religious and I meant them to be” (ibid., 207).But for the most part, Beat asseverations in no way diminished scholarly wariness about the Beat movement and its spirituality—as Prothero concludes, “the tendency among literary scholars is to see these [religious] concerns as tangential rather than constitutive” while “historians of American religion who have explored beat spirituality have tended to focus almost exclusively on the beats’ engagement with Zen and then to dismiss that engagement as haphazard” (ibid., 207).It is my contention that the mainstream scholarly neglect of Beat spirituality is in some part... (shrink)

What is morality? Is “morality” something that admits of technological enhancement? What could it possibly mean for a society to have a moral imperative to morally enhance? We are compelled to take up questions like these as we move into the future of moral bioenhancement. Each article in this issue of the Journal of Medicine and Philosophy attempts to bring some clarity as to what is meant by morality, such that one could be morally obligated to morally enhance. These articles (...) broaden the scope of the question as to the nature of human morality, what might and what might not be permitted in terms of moral bioenhancement, and explore the nature of the kinds of beings humans might become—whether human or post-human—and the moral obligations that may exist toward them. (shrink)

It is simple enough to claim that academic research institutions ought to be trustworthy. Building the culture and taking the steps necessary to earn and preserve institutional trust are, however, complex processes. The experience motivating this special report—a request for the Center for Talented Youth at Johns Hopkins University to collaborate on research regarding the genetics of intelligence—illustrates how ensuring institutional trustworthiness can be in tension with a commitment to fostering research. In this essay, we explore the historical context for (...) biomedical research institutions like Johns Hopkins that have worked to build local community trust. In so doing, we consider how the example under focus in this special report can lead to greater consideration of how research institutions balance fostering trust with their other commitments. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Merton and Buddhism: Wisdom, Emptiness and Everyday MindKristin Johnston LargenMerton and Buddhism: Wisdom, Emptiness and Everyday Mind. Edited by Bonnie Bowman Thurston. Louisville, KY: Fons Vitae, 2007. 271 pp.This particular book—Merton and Buddhism—is the fourth in a series that seeks to study world religions “through the lens of Thomas Merton’s life and writing” (p. viii). The first three volumes in the series are Merton and Sufism, Merton (...) and Hesychasm, and Merton and Judaism. This book continues in the same format and includes essays from a variety of scholars addressing various aspects of Merton’s engagement with different schools of Buddhism. It is divided into four main parts, with a fifth part that contains a helpful bibliography as well as notes on the different contributors. Additionally the text is peppered with a variety of illustrations, including a center section with many pictures of images of the Buddha from different cultural contexts. The assortment of black-and-white illustrations include pictures of people Thomas Merton (1915–1968) met on his travels, pictures he took while on his “Asian Journey,” and pictures of Merton himself and Our Lady of Gethsemani Monastery.The volume begins with two helpful essays that orient a novice reader to the volume. The first essay, by the late Roger Corless (1938–2007), is a simple, straight-forward [End Page 218] introduction to Buddhism. This is useful for readers who are drawn to this book by the desire to learn more about Merton but have no background in Buddhism itself. The second essay is by Bonnie Thurston, who describes her piece as “Merton and Buddhism 101” (p. 15). Her essay describes primarily the “when” and the “why” of Merton’s interest in Buddhism, noting that Merton was not interested in becoming a Buddhist himself, but rather believed that his own (and others’) practice of Christianity could be positively informed by Buddhism, particularly in its attention to meditation and dismantling what Merton called the “false self.”The second main part of the book is devoted to essays that each focus on Merton’s engagement with a specific Buddhist tradition. While it is clear that Merton was particularly influenced by and drawn to Zen Buddhism (Ruben Habito supplies the essay on Merton’s experience with Zen in this section), he did not limit himself to Zen, but sought out connections and experience with individuals from diverse Buddhist backgrounds. Thus, the first essay in this section details his meetings with monks from the Theravada tradition and emphasizes the central role Merton’s own monastic identity played in his understanding and evaluation of Buddhism as a whole.The second essay is of particular importance, as it discusses Merton’s engagement with Tibetan Buddhism, which many believe would have developed into a much deeper connection had his exposure to Tibetan Buddhism not come at the very end of Merton’s life. The author of this essay, Judith Simmer-Brown, notes that “Previously, Merton’s interests had been in Zen Buddhism, but after meeting Tibetans in India he felt an immediate rapport” (p. 53). The Tibetans also shared this experience. The Dalai Lama (from whom Merton received meditation instruction), Trungpa Rinpoche, and Chadral Rinpoche, among others, all recognized his spiritual depth and honesty. At the end of her essay, Simmer-Brown reflects on the strong impression the mountain Kanchenjunga made on him (this is the “seventh mountain” of Merton’s personal geography—see The Seven Mountains of Thomas Merton, by Michael Mott) and speculates as to how Merton might have continued to explore Tibetan Buddhism, had he lived beyond the year.The final essay in this section is of a different nature, but serves a very important purpose. John Keenan’s essay, “The Limits of Thomas Merton’s Understanding of Buddhism,” makes clear that Merton’s understanding of Buddhism reflects the general ignorance of Buddhism by Western Christians at that time, and thus, while Merton’s engagement with Buddhism was “welcome and mind-stretching” to his audience in the 1960s, it is “quite insufficient today for any dialogue with Buddhism, or with Zen” (p. 121). Keenan notes that a large part of the problem stems from Merton’s... (shrink)

ABSTRACT Frege characterizes judgement as the acknowledgement of the truth of a thought, appearing thereby to rule out false judgement. First in this paper I explain Frege’s characterization so that it does not have this consequence. Frege is not saying that for a subject S to judge that p is for S to acknowledge the truth of the thought that p. Rather, he is articulating judgement’s nature within self-consciousness. From within, to judge means to acknowledge a truth. Second, I suggest (...) that this articulation is centrally operative in Frege’s argument for the indefinability of truth. As Frege argues, it follows from judgement’s self-consciousness that truth is indefinable. (shrink)

Robert Kilwardby occupies an important place in the history of logic, and the history of western thought more generally. Perhaps best known to scholars for his Oxford condemnations of 1277...

Frege maintains that there are not two distinct acts, assertion and denial; rather, denying p is one and the same as asserting not-p. Wittgenstein appears not to recognise this identity in Frege, attributing to him the contrary view that a proposition may have one of two verbs, "is true" or "is false". This paper explains Wittgenstein’s attribution as a consequence of Frege’s treatment of content as theoretically prior to the act of judgment. Where content is prior to judgment, the denial (...) of p—what is rejected in asserting p—is distinct from the assertion of not-p. Wittgenstein’s own embrace of Frege’s identity is then considered, an embrace explained in part by his repudiation of Frege’s theoretical order. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Slavoj Žižek’s Hegelian ReformationGiving a Hearing to The Parallax ViewAdrian Johnston (bio)Slavoj Žižek. THE PARALLAX VIEW. Cambridge: MIT P, 2006. [PV]Near the end of a two-hour presentation at Calvin College in Grand Rapids, Michigan, on November 10, 2006, Slavoj Žižek confesses that, in terms of the intellectual ambitions nearest to his heart, “my secret dream is to be Hegel’s Luther” [“Why Only an Atheist Can Believe”]. This confession (...) comes just months after the publication of his latest major work, The Parallax View, a book described as a new magnum opus. There are ample justifications within this text to license retroactively rereading it through the lens of Žižek’s subsequent public admission that he is now preoccupied with rescuing Hegel from the numerous misinterpretations to which this giant of German idealism (who casts such a long shadow over the Continental European philosophical tradition) has been repeatedly subjected over the past two hundred years. The Parallax View, at certain points explicitly and in other places implicitly, can be seen as centered on an effort to confront aggressively the various received versions of Hegel widely accepted as official and orthodox exegetical renditions. The motif of the “parallax gap,” elaborated in a plethora of guises throughout this 2006 tome, condenses and reflects the axiomatic theses of what could be called Žižek’s Hegelian reformation.The critical assessment of The Parallax View offered here seeks to go straight to its theoretical heart by highlighting a single line of argumentation running through the full span of this text’s different moments and phases. Žižek’s own Hegelian-style conceptions of truth (as fiercely partisan rather than calmly neutral) and universality (as immanently concrete rather than transcendently abstract) validate such an interpretive approach—“universal Truth is accessible only from a partial engaged subjective position” [PV 35]. Deliberately extracting particular conceptual constellations and forcing them to link up with each other according to the plan of a certain directed philosophical agenda promises to be much more revealing of the essential features of Žižekian thought than a comprehensive survey of this latest of his major works.The specific argumentative thread to be isolated here is the new extended engagement with the terrain covered by cognitive science and the neurosciences. Apart from the task of denouncing falsifying popular pictures of Hegel, one of Žižek’s other driving ambitions in this book is the desire to formulate a fundamental ontology appropriate to the theory of subjectivity mapped out over the course of his entire intellectual itinerary (a theory informed by Kant and post-Kantian German idealism combined with Lacanian psychoanalytic metapsychology). And, herein, the articulation of such an ontology appropriately gets entangled, via reflections on the nature of the brain, with the latest instantiations of the perennial philosophical problem of the relationship between mind and [End Page 3] body. Žižek grants that the central nervous system is, in at least several undeniable and important senses, the material, corporeal ground of the subject, the bodily being without which there cannot be the parlêtre (speaking being). But, in the spirit of Schelling and Hegel (especially their philosophies of “productive” nature), the fashions in which Žižek attempts to tie together systematically a materialist ontology with an account of more-than-material, transontological subjectivity illuminate a normally obscured and ignored set of implied consequences flowing from the gesture of dissolving hard-and-fast dualist distinctions between body and mind, nature and spirit.The past few decades of philosophical engagement with the neurosciences, an engagement almost completely monopolized by the Anglo-American Analytic philosophical tradition and neglected by the Continental European philosophical tradition to an equal degree, has emphasized (to put this in the vernacular of German idealism) the naturalization of spirit resulting from the collapse of any strict nature-spirit dichotomy. The materialisms promoted by those Analytic philosophers amenable to grounding the mental on the neuronal simply assume that the outcome of folding mind and matter into each other is a becoming-material of the mind, namely, a naturalization of the spirit (that is, the mind comes to resemble the brain conceived of as just another part... (shrink)

Wittgenstein responds in his Notes on Logic to a discussion of Russell's Principles of Mathematics concerning assertion. Russell writes: "It is plain that, if I may be allowed to use the word assertion in a non-psychological sense, the proposition "p implies q" asserts an implication, though it does not assert p or q. The p and the q which enter into this proposition are not strictly the same as the p or the q which are separate propositions." (PoM p35) Wittgenstein (...) replies: "Assertion is merely psychological. In not-p, p is exactly the same as if it stands alone; this point is absolutely fundamental." (NB p95) Wittgenstein's response is intriguing, not least because of the centrality to his Tractatus of the idea that a proposition says something. This paper will examine that idea, distinguishing it from 'merely psychological' assertion, and explore in this context how we should understand the occurrence of a Tractarian proposition within another. (shrink)

We show that a morphism of locales is open if and only if all its pullbacks are skeletal in the sense of [P.T. Johnstone, Factorization theorems for geometric morphisms, II, in: Categorical Aspects of Topology and Analysis, in: Lecture Notes in Math., vol. 915, Springer-Verlag, 1982, pp. 216–233], i.e. pulling back along them preserves denseness of sublocales . This result may be viewed as the ‘dual’ of the well-known characterization of proper maps as those which are stably closed. We also (...) investigate the circumstances in which a particular sublocale, or set of sublocales, of a given locale, may be ‘declared closed’. (shrink)

The article provides an example of the application of the techniques and results of historical linguistics to traditional problems in the philosophy of language. It takes as its starting point the dispute about the nature of facts that arose from the 1950 Aristotelian Society debate between J. L. Austin and P. F. Strawson. It is shown that, in some cases, expressions containing the noun fact refer to actions and events; while in other cases, such expressions do not have a referring (...) function at all. Thus, nothing corresponding to Strawson's 'pseudomaterial correlate' need be postulated in order to account for the reference of the noun fact. It is suggested that many philosophically problematic expressions may be better understood by tracing their historical evolution in natural language. (shrink)

Several cases which have been considered by the courts in recent years have highlighted the legal dilemmas facing doctors whose decisions result in the ending of a patient's life. This paper considers the case of Dr Cox, who was convicted of attempting to murder one of his patients, and explores the roles of motive, diminished responsibility and consent in cases of "mercy killing". The Cox decision is compared to that of Tony Bland and Janet Johnstone, in which the patients were (...) in a persistent vegetative state. In all three cases, the doctors believed that their patients' quality of life was so poor that their continued existence was of no benefit to them, and decided that their lives should not be unduly prolonged, yet the doctor who was prosecuted was the one whose dying patient had requested that her death be hastened. The paper examines the law's seemingly contradictory approaches to such cases. (shrink)

Volume 41, Issue 3, August 2020, Page 301-303.